vanZ-A

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glycopeptide resistance protein VanZ-A

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to vanZ-A

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Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: whole-genome sequencing and PCR confirmation
Drug Classes: VANCOMYCIN, vancomycin, teicoplanin, glycopeptides
Organisms: Enterococcus faecalis, Enterococcus faecium, Lactococcus garvieae, Enterococcus faecium BT22, Niallia circulans
Geographic Location: Brazil, Chettia Chlef Hospital, Italy
Alleles: 2
Papers: 5
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
VanZ-A	Card DatabaseReference Gene CatalogReslit	5	VANCOMYCIN, vancomycin +1	Enterococcus faecalis +3	Brazil, Chettia Chlef Hospital	1998, 2006, 2022, 2023	AB247327.1	BAE98133.1
vanZ-like domain	Reslit	1	glycopeptides	Lactococcus garvieae	Italy	2022	SAMEA12289652\|SAMEA12289653\|SAMEA12289654	-

Papers5

Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.

PMID 17021204 · 2006

Gene Information

Gene Name: vanZ-A
Allele: VanZ-A
Encodes: glycopeptide resistance protein VanZ-A
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AB247327.1
Protein Accession: BAE98133.1
Notes: ARO:3002962

Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.

PMID 17021204 · 2006

Gene Information

Gene Name: vanZ-A
Allele: VanZ-A
Encodes: glycopeptide resistance protein VanZ-A
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Enterococcus faecalis
Sequence Accession: AB247327.1
Protein Accession: BAE98133.1
Notes: ARO:3002962

Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.

PMID 34718966 · 2022

The study characterizes the genetic structure of vancomycin-resistant Enterococcus faecium isolates displaying a VanD phenotype with a vanA genotype, highlighting the presence of various resistance genes and genetic variations within the van transposon.

Gene Information

Gene Name: vanZ-A
Allele: VanZ-A
Encodes: glycopeptide resistance determinant
Source Database: Reslit
Confers Resistance To: vancomycinteicoplanin
Organisms Tested In: • Enterococcus faecium
Geographic Location: Brazil
Validation Method: whole-genome sequencing and PCR confirmation
Sequence Accession: QHLB00000000|MXAT00000000|QHLC00000000|QNUP00000000|MVGF00000000|MVGH00000000|QNUQ00000000|QHLD00000000|MVGJ00000000

Evidence of pediatric sepsis caused by a drug resistant Lactococcus garvieae contaminated platelet concentrate.

PMID 35475418 · 2022

The study identifies several AMR genes in Lactococcus garvieae isolates from pediatric sepsis cases, including lsa(D), mdt(A), and various penicillin-binding proteins, highlighting the emergence of drug-resistant strains in blood transfusions.

Gene Information

Gene Name: vanZ-A
Allele: vanZ-like domain
Encodes: protein
Source Database: Reslit
Mechanism: decreases sensitivity to some lipoglycopeptide antibiotics
Confers Resistance To: glycopeptides
Organisms Tested In: • Lactococcus garvieae
Geographic Location: Italy
Validation Method: whole-genome sequencing and antimicrobial susceptibility testing
Sequence Accession: SAMEA12289652|SAMEA12289653|SAMEA12289654

Draft genome sequencing data of Enterococcus faecium BT22, a vancomycin-resistant opportunistic pathogen isolated from hospital effluents.

PMID 38075608 · 2023

The study identified 12 antibiotic resistance genes and one virulence gene in strain BT22, including genes conferring resistance to aminoglycosides, macrolides, tetracyclines, and vancomycin.

Gene Information

Gene Name: vanZ-A
Allele: VanZ-A
Encodes: Glycopeptide resistance protein
Source Database: Reslit
Mechanism: Modification of cell wall precursors
Confers Resistance To: vancomycin
Organisms Tested In: • Enterococcus faecium BT22
Geographic Location: Chettia Chlef Hospital
Validation Method: Genome sequencing and annotation
Sequence Accession: JASSVD010000000

vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans.

PMID 9687406 · 1998

Gene Information

Gene Name: vanZ-A
Allele: VanZ-A
Encodes: glycopeptide resistance protein VanZ-A
Source Database: Reference Gene Catalog
Confers Resistance To: VANCOMYCIN
Organisms Tested In: • Niallia circulans
Sequence Accession: Y17304.1
Protein Accession: CAB61225.1

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Allele

Database

Papers

Drug Classes

Organisms

Countries

Years

Sequence Accession

Protein Accession

VanZ-A

Card DatabaseReference Gene CatalogReslit

VANCOMYCIN, vancomycin +1

Enterococcus faecalis +3

Brazil, Chettia Chlef Hospital

1998, 2006, 2022, 2023

AB247327.1

BAE98133.1

vanZ-like domain

Reslit

glycopeptides

Lactococcus garvieae

Italy

2022

SAMEA12289652|SAMEA12289653|SAMEA12289654

vanZ-A

Gene Information

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vanZ-A

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