vanrg2

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D,D-peptidase

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Validation StatusCandidate

Overview

Validation Method: presence in ST1 isolates and absence in ST37 isolates
Drug Classes: vancomycin
Organisms: Clostridioides difficile
Geographic Location: Europe|Asia
Papers: 1
Databases: Reslit

Papers1

Differences in virulence and drug resistance between Clostridioides difficile ST37 and ST1 isolates.

PMID 40346827 · 2025

ST37 isolates exhibited higher resistance to chloramphenicol and tetracycline compared to ST1 isolates, with the presence of catQ and tetM genes in ST37 but not in ST1. ST1 isolates showed higher resistance to rifaximin, and the R505K mutation in rpoB was detected in rifaximin-resistant ST37 isolates.

Gene Information

Gene Name: vanrg2
Allele: vanRG2
Encodes: D,D-peptidase
Source Database: Reslit
Confers Resistance To: vancomycin
Organisms Tested In: • Clostridioides difficile
Geographic Location: Europe|Asia
Validation Method: presence in ST1 isolates and absence in ST37 isolates
Sequence Accession: PRJNA1160995|ERR047167

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vanrg2

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vanrg2

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