Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
streptogramin vat acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vatA | Card DatabaseReslit | 7 | quinupristin dalfopristin, streptogramin a +6 | Staphylococcus aureus +4 | France|Spain, USA, Spain, coastal environments|coastal regions | 2001, 2014, 2015, 2019, 2021, 2023 | L07778.1 | AAA26683.1 |
| vat | Reslit | 6 | streptogramin a, macrolides +2 | Staphylococcus aureus +5 | France, Europe|North America|Asia, Venezuela, Canada|United States, Brazil|Belgium, Mayurbhanj, Odisha, India|India | 1999, 2020, 2023, 2025 | JAAGVC000000000|JAAGVB000000000|JAAGVA000000000|JAAGUZ000000000|JAAGUY000000000|JAAGUX000000000 | - |
| Vat(A) | Card DatabaseReference Gene CatalogReslit | 5 | quinupristin dalfopristin, streptogramin b +2 | Staphylococcus aureus +2 | Germany, Europe | 1993, 2003, 2022, 2023 | Y00688|M18086|X03216|V01278|S67449|X56353|AF117258|U19459|AF015628|Y15856|AF033191 | AAA26683.1 |
| vat(A) | ResFinder Database | 1 | PRISTINAMYCIN IIA, DALFOPRISTIN +1 | Staphylococcus aureus | - | 1993 | L07778 | - |
Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci.
The study identified and characterized various AMR genes, including ermA, ermC, msrA, linA/linA′, vga, vgb, and vat, which confer resistance to macrolides, lincosamides, and streptogramins in staphylococci.
Methicillin-resistant, quinupristin-dalfopristin-resistant Staphylococcus aureus with reduced sensitivity to glycopeptides.
The study identified several AMR genes, including vatA, vgbA, vatB, and vgaB, which contribute to quinupristin-dalfopristin resistance in methicillin-resistant Staphylococcus aureus strains.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus.
The study describes a multiplex PCR assay for detecting nine clinically relevant antibiotic resistance genes in Staphylococcus aureus, including mecA, aacA-aphD, erm(A), erm(C), tetK, tetM, and vat genes, which confer resistance to methicillin, aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, and quinupristin-dalfopristin.
Potential for reduction of streptogramin A resistance revealed by structural analysis of acetyltransferase VatA.
The study characterizes the acetyltransferase VatA from Staphylococcus aureus, which confers resistance to streptogramin A by acetylating the antibiotic, and identifies critical residues involved in its activity through structural and mutagenesis analysis.
Thirty-minute screening of antibiotic resistance genes in bacterial isolates with minimal sample preparation in static self-dispensing 64 and 384 assay cards.
The study presents a rapid LAMP-based method for detecting antibiotic resistance genes in bacterial isolates with minimal sample preparation, demonstrating successful detection of various resistance genes including aadD, bacA, ble, mepA, norA, qacA, and tetM.
Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains.
The study identified multiple antimicrobial resistance genes in Elizabethkingia meningoseptica strains, including beta-lactamases, tetracycline resistance genes, and efflux pumps, indicating a multidrug-resistant profile.
Molecular Characterization and Antimicrobial Susceptibilities of Nocardia Species Isolated from the Soil; A Comparison with Species Isolated from Humans.
The study identified various antimicrobial resistance genes in Nocardia species isolated from soil, including beta-lactamase, aminoglycoside modifying enzymes, macrolide resistance genes, chloramphenicol resistance proteins, vancomycin resistance, and multidrug efflux pumps. Some soil N. cyriacigeorgica strains exhibited distinct genetic profiles suggesting possible new subspecies or species.
Genomic Background and Phylogeny of cfiA-Positive Bacteroides fragilis Strains Resistant to Meropenem-EDTA.
The study identifies two new metallo-beta-lactamase genes, cfiA14b and cfiA28, in Bacteroides fragilis strains resistant to meropenem-EDTA. Additionally, various other AMR genes such as aadS, aac(3'), ermF, lnu(AN2), vatA, mef(En2), tetX, tetQ, cat, bexA, bexB, qacE, cusR, mexAB-oprM, mexJK-oprM, mexXY-oprM, acrEF-tolC, and mdtEF-tolC were characterized.
River Biofilms Microbiome and Resistome Responses to Wastewater Treatment Plant Effluents Containing Antibiotics.
The study identified various antibiotic resistance genes (ARGs) in river biofilms upstream and downstream of a wastewater treatment plant (WWTP), including qnrA, qnrS, mfsA, ermC, ermX, macB, mefA_10, cat, catB3, aadB, aph(3')-III, AAC(3)-Ib, bacA_1, blaPer-1, blaIMP, blaTEM, blaKPC, blaDHA, cblA, ermC, ermY, ermX, mdtL, cusF, copD, qacA, mecA, dfrF, arnA, sul1, sulA, vat(A), IS6100, ISS1N, Intl1, blaCTX-M, blaIMP, mefA_10, tolC, mdfF, acrA, dfrA27, aac(6')-IIa, vanA, intl3, and TTV. These genes were associated with resistance to various antibiotics such as fluoroquinolones, macrolides, chloramphenicol, aminoglycosides, beta-lactams, polymyxins, sulfonamides, and others. The study also found that the resistome composition varied between upstream and downstream sites, indicating the impact of WWTP effluents on the distribution of ARGs in river biofilms.
Antimicrobial Resistance in Feedlot Cattle: Resistome Composition and Associations with Antimicrobial Drug Exposures
The study identified several AMR genes in fecal samples from beef feedlot cattle, including genes conferring resistance to tetracycline, macrolide-lincosamide-streptogramin (MLS), aminoglycosides, beta-lactams, and others. These genes were detected using target-enriched metagenomic sequencing.
Enrichment of antibiotic resistant genes and pathogens in face masks from coastal environments.
The study identified 64 antibiotic-resistance genes (ARGs) and 12 mobile gene elements (MGEs) in the plastisphere of face masks, with significant enrichments in tetracycline, multidrug, macrolide-lincosamide-streptogramin B (MLSB), and phenicol-resistant genes compared to sediments.
Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain.
The study identifies multiple antibiotic resistance genes in the highly pathogenic Proteus mirabilis strain MCS, highlighting its multidrug-resistant profile. Key genes include tetA, aac(6')-Iq, aac(6')-Ib', aadA, dfrA1, blaOXA-9, blaCTX-M-2, vat, catA2, sul1, qacEdeltal, tetQ, blaTEM-135, aadA2, aph(3')-Ia, aph(6)-Id, aph(3'')-lb, and sulI.
Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue.
The study reports the successful mutasynthesis of pristinamycin I derivatives by targeting the phenylglycine residue, highlighting the role of pglA and snaE1 in pristinamycin biosynthesis.
Unveiling community structure, antimicrobial resistance, and virulence factor of a wastewater sample of dairy farm located in mayurbhanj, odisha, india.
The study identified several antimicrobial resistance (AMR) genes in a dairy wastewater sample, including beta-lactamases, aminoglycoside acetyltransferases, tetracycline resistance proteins, quinolone resistance proteins, and macrolide ribosome methyltransferases. These genes were found in various bacterial species such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics.
Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics.
Sequence of a staphylococcal gene, vat, encoding an acetyltransferase inactivating the A-type compounds of virginiamycin-like antibiotics.
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