Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
streptogramin vat acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vatB | Card DatabaseReslit | 8 | quinupristin dalfopristin, streptogramin a +3 | Staphylococcus aureus +4 | France|Spain, China, North America|Europe|International Space Station, Europe|United States|Asia | 2001, 2020, 2021, 2022, 2023 | U19459.1 | AAA86871.1 |
| Vat(B) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | quinupristin dalfopristin, streptogramin a +4 | Staphylococcus aureus +2 | Germany, global | 1995, 2003, 2023 | Y00688|M18086|X03216|V01278|S67449|X56353|AF117258|U19459|AF015628|Y15856|AF033191 | AAA86871.1 |
| vat(B) | ResFinder Database | 1 | PRISTINAMYCIN IIA, DALFOPRISTIN +1 | Staphylococcus aureus | - | - | U19459 | - |
Methicillin-resistant, quinupristin-dalfopristin-resistant Staphylococcus aureus with reduced sensitivity to glycopeptides.
The study identified several AMR genes, including vatA, vgbA, vatB, and vgaB, which contribute to quinupristin-dalfopristin resistance in methicillin-resistant Staphylococcus aureus strains.
Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus.
The study describes a multiplex PCR assay for detecting nine clinically relevant antibiotic resistance genes in Staphylococcus aureus, including mecA, aacA-aphD, erm(A), erm(C), tetK, tetM, and vat genes, which confer resistance to methicillin, aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, and quinupristin-dalfopristin.
Rapid Diagnostic Approaches for Antimicrobial Resistance
The paper discusses various rapid antimicrobial resistance testing methods, including molecular techniques like qPCR, DNA microarrays, Luminex xMAP, and next-generation sequencing (NGS), highlighting their roles in detecting resistance genes such as blaCTX-M, blaTEM, blaSHV, blaKPC, blaNDM, blaOXA-48, blaVIM, blaIMP, mecA, mecC, vanA, vanB, aacA-aphD, tetK, tetM, ermA, ermC, vatA, vatB, and vatC in different bacterial species.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Complete genome analysis of a virulent Vibrio scophthalmi strain VSc190401 isolated from diseased marine fish half-smooth tongue sole, Cynoglossus semilaevis.
The study identified several AMR genes in Vibrio scophthalmi strain VSc190401, including those conferring resistance to aminoglycosides, fluoroquinolones, tetracyclines, and polymyxins. Some of these genes were validated experimentally.
Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus.
The study identifies various antimicrobial resistance genes in CoNS species, including mecA, norA, vatB, vgaB, lsaB, erm(43), ermT, fusD, fusF, and salA, which confer resistance to beta-lactams, fluoroquinolones, lincosamides, macrolides, streptogramins, fusidic acid, and other antimicrobial agents. These genes are associated with horizontal gene transfer and recombination, highlighting the dynamic nature of CoNS evolution.
Bacillus licheniformis-fermented products and enramycin differentially modulate microbiota and antibiotic resistome in the cecal digesta of broilers.
Enramycin treatment promoted the expression of bcrA, vanRI, and lsaE resistance genes while suppressing ANT(6)-Ib, vatB, and ugd. BLFPs suppressed aminoglycoside and streptogramin resistance genes but enhanced macrolide and aminocoumarin resistance genes.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
Fecal antibiotic resistance genes were transferred through the distribution of soil-lettuce-snail food chain.
The study identified several antibiotic resistance genes (ARGs) such as aacA43, mel_1, vanRB, tetM, tnpA-2, sul1, sul2, ermF, and vatB that were transferred through the soil-lettuce-snail food chain. These genes conferred resistance to various antibiotics including aminoglycosides, tetracyclines, sulfonamides, MLSB, and vancomycin.
Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue.
The study reports the successful mutasynthesis of pristinamycin I derivatives by targeting the phenylglycine residue, highlighting the role of pglA and snaE1 in pristinamycin biosynthesis.
Diversity among the gram-positive acetyltransferases inactivating streptogramin A and structurally related compounds and characterization of a new staphylococcal determinant, vatB.
Diversity among the gram-positive acetyltransferases inactivating streptogramin A and structurally related compounds and characterization of a new staphylococcal determinant, vatB.
Diversity among the gram-positive acetyltransferases inactivating streptogramin A and structurally related compounds and characterization of a new staphylococcal determinant, vatB.
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