vat(C)

streptogramin vat acetyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to vat(C)

Browse AMR rules for vat(C)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: multiplex PCR assay
Drug Classes: quinupristin dalfopristin, streptogramin a, STREPTOGRAMIN, PRISTINAMYCIN IIA, DALFOPRISTIN, VIRGINIAMYCIN M
Organisms: Staphylococcus cohnii, Staphylococcus aureus, Staphylococcus cohnii subsp. cohnii, Staphylococcus aureus RN4220
Geographic Location: Algiers, Germany
Alleles: 3
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
vatC	Card DatabaseReslit	2	streptogramin a	Staphylococcus cohnii +2	Algiers	1998	AF015628.1	AAC61671.1
Vat(C)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	4	quinupristin dalfopristin, STREPTOGRAMIN +3	Staphylococcus aureus +1	Germany	1998, 2003	Y00688\|M18086\|X03216\|V01278\|S67449\|X56353\|AF117258\|U19459\|AF015628\|Y15856\|AF033191	AAC61671.1
vat(C)	ResFinder Database	1	PRISTINAMYCIN IIA, DALFOPRISTIN +1	Staphylococcus cohnii	-	1998	AF015628	-

Papers2

1

Gene Information

Gene Name: vat(C)
Allele: vatC
Encodes: streptogramin vat acetyltransferase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Staphylococcus cohnii
Sequence Accession: AF015628.1
Protein Accession: AAC61671.1
Notes: ARO:3002842

2

Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus.

PMID 12958230 · 2003

The study describes a multiplex PCR assay for detecting nine clinically relevant antibiotic resistance genes in Staphylococcus aureus, including mecA, aacA-aphD, erm(A), erm(C), tetK, tetM, and vat genes, which confer resistance to methicillin, aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, and quinupristin-dalfopristin.

Gene Information

Gene Name: vat(C)
Allele: Vat(C)
Encodes: streptogramin A resistance
Source Database: Reslit
Confers Resistance To: quinupristin dalfopristin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Germany
Validation Method: multiplex PCR assay
Sequence Accession: Y00688|M18086|X03216|V01278|S67449|X56353|AF117258|U19459|AF015628|Y15856|AF033191

3

Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics.

PMID 9661023 · 1998

The study identified two novel genes, vatC and vgbB, on a plasmid from Staphylococcus cohnii subsp. cohnii BM10711, which confer resistance to streptogramin A and B, respectively.

Gene Information

Gene Name: vat(C)
Allele: vatC
Encodes: acetyltransferase
Source Database: Reslit
Confers Resistance To: streptogramin a
Organisms Tested In: • Staphylococcus cohnii subsp. cohnii
• Staphylococcus aureus RN4220
Geographic Location: Algiers
Validation Method: cloning in S. aureus RN4220 and disk diffusion
Sequence Accession: AFO15628

4

Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics.

PMID 9661023 · 1998

Gene Information

Gene Name: vat(C)
Allele: Vat(C)
Encodes: streptogramin A O-acetyltransferase Vat(C)
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: STREPTOGRAMINPRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Staphylococcus cohnii
Sequence Accession: AF015628.1
Protein Accession: AAC61671.1
Notes: Streptogramin A acetyltransferase

5

Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics.

PMID 9661023 · 1998

Gene Information

Gene Name: vat(C)
Allele: Vat(C)
Encodes: streptogramin A O-acetyltransferase Vat(C)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: STREPTOGRAMINPRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Staphylococcus cohnii
Sequence Accession: AF015628.1
Protein Accession: AAC61671.1
Notes: Streptogramin A acetyltransferase

6

Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics.

PMID 9661023 · 1998

Gene Information

Gene Name: vat(C)
Allele: Vat(C)
Encodes: streptogramin A O-acetyltransferase Vat(C)
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: STREPTOGRAMINPRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Staphylococcus cohnii
Sequence Accession: AF015628.1
Protein Accession: AAC61671.1
Notes: Streptogramin A acetyltransferase

7

Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics.

PMID 9661023 · 1998

Gene Information

Gene Name: vat(C)
Allele: vat(C)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: PRISTINAMYCIN IIADALFOPRISTINVIRGINIAMYCIN M
Organisms Tested In: • Staphylococcus cohnii
Sequence Accession: AF015628
Notes: Streptogramin A acetyltransferase

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