Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
streptogramin vat acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vatD | Card DatabaseReslit | 7 | virginiamycin s, streptogramins +1 | Enterococcus faecium +5 | Australia, Danakil Depression, Afar Region, Ethiopia, Europe|Africa|North America|South America|Asia|Oceania, United States | 2008, 2021, 2023, 2025 | AF368302.1 | AAK84316.1 |
| Vat(D) | Reference Gene CatalogResFinder DatabaseReslit | 6 | streptogramin a, pleuromutilins +5 | Enterococcus faecium +3 | Denmark, Brazil | 1993, 2001, 2006, 2022, 2024 | AF368302 | AAA24783.1 |
| vat(D) | ResFinder Database | 1 | PRISTINAMYCIN IIA, DALFOPRISTIN +1 | Enterococcus faecium | - | 1993 | L12033 | - |
Indication of transposition of a mobile DNA element containing the vat(D) and erm(B) genes in Enterococcus faecium.
The study identifies the transposition of a mobile DNA element containing the vat(D) and erm(B) genes in Enterococcus faecium, demonstrating their co-transfer and physical linkage.
Activity of a new oral streptogramin, XRP2868, against gram-positive cocci harboring various mechanisms of resistance to streptogramins.
The study identified several AMR genes including erm(A), erm(C), erm(B), vat(D), vgb(A), and vga(A) that confer resistance to streptogramins. Mutations in the rplV gene, encoding ribosomal protein L22, also contributed to resistance against streptogramin B.
Antibiotic resistance in Escherichia coli and Enterococcus spp. isolates from commercial broiler chickens receiving growth-promoting doses of bacitracin or virginiamycin.
The study identified the presence of bacitracin resistance gene bcrR, virginiamycin resistance genes vatD and ermB in Enterococcus spp. isolates from broiler chickens.
Sequence characterisation and novel insights into bovine mastitis-associated Streptococcus uberis in dairy herds.
The study identified antibiotic resistance genes in Streptococcus uberis isolates, including a multidrug resistance cluster consisting of mel/mef(A), mrsE, vatD, and lnuD, which confer resistance to various antibiotics such as lincosamides, macrolides, oxazolidinones, phenicols, pleuromutilins, streptogramins, and tetracyclines.
ggMOB: Elucidation of genomic conjugative features and associated cargo genes across bacterial genera using genus-genus mobilization networks.
The study identifies various conjugative features and associated cargo genes, highlighting the significant role of conjugation in the spread of antimicrobial resistance (AMR) across bacterial genera. Key AMR genes such as Tn916, CTn341, SXT, ICEEc2, ICEclc, Tn1549, and Tn4555 were found to be prevalent in conjugative genomes, demonstrating their involvement in the dissemination of resistance traits.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
The gut microbiota of wild birds undergoing rehabilitation as a reservoir of multidrug-resistant enterococci in a metropolitan area in Brazil.
The study identified multiple antimicrobial resistance genes in enterococci isolated from wild birds, including genes conferring resistance to aminoglycosides, erythromycin, tetracycline, and streptogramins.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Detection of a streptogramin A O-acetyltransferase gene (vatD) in the chromosome of Clostridium botulinum isolated from infants in the United States.
The study reports the detection of the vatD gene, which confers resistance to streptogramin A antibiotics, in the chromosome of Clostridium botulinum isolates from infants in the United States.
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD.
The study identifies VatD as a key enzyme responsible for streptogramin resistance through acetylation of group A streptogramins. Fragment-based drug discovery was used to identify potential inhibitors of VatD, revealing several promising starting points for inhibitor development.
Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145.
Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145.
Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145.
No comments yet. Be the first to comment!