Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ATP-binding cassette (ABC) transporter
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vga(A)v | Reslit | 4 | lincosamides, tiamulin +3 | Staphylococcus aureus +1 | Switzerland, France, Europe|Israel|United Kingdom|Republic of Ireland|Italy | 2005, 2011, 2013, 2019 | KC539823 | - |
| vga(A)V | Reslit | 2 | phenicols, lincosamides +3 | Staphylococcus aureus +1 | Germany, Japan | 2023, 2024 | NCBI BioProject PRJNA931015|PRJNA814867|PRJNA842861 | - |
Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci.
The study identifies and characterizes the Vga proteins, including vga(A), vga(A)v, vga(B), and Lmo0919, as conferring resistance to streptogramin A (SGA) and lincosamides in staphylococci. It also shows that vga(B) increases resistance to pristinamycin, a combination of SGA and SGB.
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland.
The study identifies the presence of methicillin-resistant Staphylococcus aureus (MRSA) in slaughter pigs in Switzerland, highlighting the emergence of the unusual sequence type ST49. It reports various AMR genes such as mecA, blaZ, tet(M), tet(K), erm(A), erm(C), ant(9)-Ia, str, dfr(G), and vga(A)v, which confer resistance to β-lactams, tetracycline, macrolides, lincosamides, streptogramins B, spectinomycin, streptomycin, trimethoprim, and tiamulin.
Resistance Genes Underlying the LS(A) Phenotype of Staphylococcal Isolates from France.
The study identifies vga(A) and its variants, particularly vga(A)v, as the primary genes responsible for the LS(A) phenotype in staphylococcal isolates from France, with vga(A)v being the most prevalent. The Tn5406 transposon was found to support the dissemination of vga(A)v.
Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.
The study identifies silenced antibiotic resistance genes in Staphylococcus aureus, highlighting the prevalence of transient antibiotic resistance due to mutations that inactivate resistance genes, leading to apparent susceptibility but potential re-emergence of resistance.
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
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