Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
streptogramin vgb lyase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vgbA | Card DatabaseReslit | 3 | quinupristin dalfopristin, streptogramins | Staphylococcus aureus +1 | France|Spain, Canada|United States | 2001, 2023 | M20129.1 | AAA98349.1 |
| vgb | Reslit | 4 | streptogramin b, quinupristin dalfopristin +1 | Staphylococcus aureus +3 | France, Europe|North America|Asia, Europe|United States|Asia | 1999, 2022, 2023 | NC_002745|NC_002758|BX571856|NC_009632|AB127982|AJ810120|AB261975|AB435013|AF422651|AF422696|AB063172|AB063173|AB096217|DQ106887|HE681097|AB425823|AB425824|GU122149|LC425379.1|AB872254|KX385846.1|AB512767|AB462393|AB478780|AM990992|AB505629 | - |
| Vgb(A) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | streptogramin b, STREPTOGRAMIN +3 | Staphylococcus aureus +3 | - | 1988, 2006, 2023 | M20129.1 | AAA98349.1 |
| vgb(A) | ResFinder Database | 1 | PRISTINAMYCIN IA, VIRGINIAMYCIN S +1 | Staphylococcus aureus | - | 1988 | M20129 | - |
Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci.
The study identified and characterized various AMR genes, including ermA, ermC, msrA, linA/linA′, vga, vgb, and vat, which confer resistance to macrolides, lincosamides, and streptogramins in staphylococci.
Effects of genes encoding resistance to streptogramins A and B on the activity of quinupristin-dalfopristin against Enterococcus faecium.
The study identifies the genes ermB, vgb, and satA as conferring resistance to quinupristin-dalfopristin in Enterococcus faecium. These genes were experimentally validated through cloning and MIC testing.
Methicillin-resistant, quinupristin-dalfopristin-resistant Staphylococcus aureus with reduced sensitivity to glycopeptides.
The study identified several AMR genes, including vatA, vgbA, vatB, and vgaB, which contribute to quinupristin-dalfopristin resistance in methicillin-resistant Staphylococcus aureus strains.
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Activity of a new oral streptogramin, XRP2868, against gram-positive cocci harboring various mechanisms of resistance to streptogramins.
The study identified several AMR genes including erm(A), erm(C), erm(B), vat(D), vgb(A), and vga(A) that confer resistance to streptogramins. Mutations in the rplV gene, encoding ribosomal protein L22, also contributed to resistance against streptogramin B.
Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics.
Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics.
Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics.
Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics.
Nucleotide sequence of a staphylococcal plasmid gene, vgb, encoding a hydrolase inactivating the B components of virginiamycin-like antibiotics.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
Antimicrobial Resistance in Feedlot Cattle: Resistome Composition and Associations with Antimicrobial Drug Exposures
The study identified several AMR genes in fecal samples from beef feedlot cattle, including genes conferring resistance to tetracycline, macrolide-lincosamide-streptogramin (MLS), aminoglycosides, beta-lactams, and others. These genes were detected using target-enriched metagenomic sequencing.
Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue.
The study reports the successful mutasynthesis of pristinamycin I derivatives by targeting the phenylglycine residue, highlighting the role of pglA and snaE1 in pristinamycin biosynthesis.
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