Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| vmlR | Card Database | 1 | - | Bacillus subtilis subsp. subtilis str. 168 | - | - | NC_000964.3 | NP_388442.1 |
| VmlR | Card DatabaseReference Gene CatalogReslit | 6 | virginiamycin m, lincomycin +7 | Bacillus subtilis +2 | Tibet|farmland soils|Zhejiang province | 2018, 2019, 2022 | EMD-0177|EMD-0176|6HA8|6HA1 | BAA19394.1 |
| vml R | Reslit | 1 | lincomycin, streptogramin a +1 | Bacillus anthracis | North America|South America|Europe|Asia|Africa|Oceania | 2021 | AE017334.2|AE017336 | - |
Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR.
The study identifies VmlR as a ribosome protection protein that confers resistance to virginiamycin M, lincomycin, and tiamulin in Bacillus subtilis through an allosteric mechanism.
Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR.
Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR.
ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life.
The study identifies and characterizes various ABCF ATPases involved in ribosome function and antibiotic resistance, highlighting their structural and functional diversity across different organisms.
The roles of antimicrobial resistance, phage diversity, isolation source and selection in shaping the genomic architecture of Bacillus anthracis.
The study identifies ten AMR genes in B. anthracis, highlighting their distribution across global isolates and their association with population genomic structure. Key genes include mph L, bla 1, fos B, bla 2, vml R, bcII, tem -116, cfr C, dfr G, and oxa -59, each with distinct resistance mechanisms and geographic prevalence.
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation and (p)ppGpp.
The study identifies VmlR as a Bacillus subtilis ABCF ATPase that confers resistance to pleuromutilin, lincosamide, and type A streptogramin antibiotics. It also elucidates the regulatory mechanisms governing VmlR expression.
Active antibiotic resistome in soils unraveled by single-cell isotope probing and targeted metagenomics.
The study identifies various AMR genes and mutations in soil samples, highlighting the active resistome in agricultural and natural soils. Key findings include the detection of genes like gyrA, bcrA, and macB, which confer resistance to antibiotics such as ciprofloxacin and meropenem. The research emphasizes the importance of phenotypic resistance assessment in environmental AMR monitoring.
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