vmlr2

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ABC transporter

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to vmlr2

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: mediates resistance to nucleoside antibiotics and PLS A antibiotics
Validation Method: expression in B. subtilis ΔvmlR and MIC testing
Drug Classes: pleuromutilins, lincosamides, streptogramin a
Organisms: Neobacillus vireti, Bacillus subtilis
Papers: 1
Databases: Reslit

Papers1

Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR.

PMID 36951104 · 2023

The study identifies and characterizes three genome-encoded ABCF factors, CplR, VmlR2, and Ard1, which confer intrinsic antibiotic resistance in Gram-positive bacteria. CplR provides resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics, VmlR2 confers resistance to nucleoside and PLS A antibiotics, and Ard1 provides self-resistance to nucleoside antibiotics.

Gene Information

Gene Name: vmlr2
Allele: vmlR2
Encodes: ABC transporter
Source Database: Reslit
Mechanism: mediates resistance to nucleoside antibiotics and PLS A antibiotics
Confers Resistance To: pleuromutilinslincosamidesstreptogramin a
Organisms Tested In: • Neobacillus vireti
• Bacillus subtilis
Validation Method: expression in B. subtilis ΔvmlR and MIC testing
Sequence Accession: WP_011861613.1|WP_003234144.1|WP_024026878.1

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vmlr2

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vmlr2

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