walH

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WalH protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to walH

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: RNA-Seq analysis showing >10-fold increased expression in KG-18 compared to KG-03
Drug Classes: vancomycin
Organisms: Staphylococcus aureus
Geographic Location: Japan
Papers: 1
Databases: Reslit

Papers1

IS256-Mediated Overexpression of the WalKR Two-Component System Regulon Contributes to Reduced Vancomycin Susceptibility in a Staphylococcus aureus Clinical Isolate.

PMID 31474962 · 2019

The study identifies mprF and dltABCD as key contributors to DAP resistance in S. aureus isolates, with a non-synonymous mutation in mprF (Trp 424 Cys) playing a significant role in increased DAP resistance.

Gene Information

Gene Name: walH
Allele: walH
Encodes: WalH protein
Source Database: Reslit
Confers Resistance To: vancomycin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Japan
Validation Method: RNA-Seq analysis showing >10-fold increased expression in KG-18 compared to KG-03
Sequence Accession: AP019542|AP019543|AP019545

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walH

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walH

Gene Information