Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
histidine kinase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S9P | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T217K | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| G223S | - | - | Staphylococcus aureus | vancomycinvancomycin|daptomycin|dalbavancin | Reslit | Candidate |
| A243T | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| R282C | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| V383I | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| S437F | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| F483I | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| H576R | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| D274A | - | gain-of-function | Bacillus subtilis | cef | Reslit | Candidate |
| A567V | - | - | Staphylococcus aureus | vancomycin|daptomycin|dalbavancindaptomycin | Reslit | Candidate |
| I594M | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T1182I | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| G223D | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| K337E | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| S221P | reduced autophosphorylation status of WalK, thereby decreasing the phosphorylation and transcriptional activity of WalR, enhanced vancomycin resistance, single resistance variant, cell wall metabolism sensor histidine kinase WalK | Staphylococcus aureus | vancomycindaptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| R123K | - | - | Staphylococcus aureus | daptomycin | Reslit | Candidate |
| N283E | - | - | L. monocytogenes | penicillin | Reslit | Candidate |
| Y272A | - | - | Staphylococcus epidermidis | dalbavancin | Reslit | Candidate |
| Y505H | - | - | Staphylococcus aureus | vancomycin|daptomycin | Reslit | Candidate |
| N70K | - | - | Staphylococcus haemolyticus | vancomycin | Reslit | Candidate |
| R280Q | - | - | Staphylococcus haemolyticus | vancomycin | Reslit | Candidate |
| T357I | - | - | - | daptomycin | Reslit | Candidate |
| M220I | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| Y225N | - | - | Staphylococcus aureus | daptomycin | Reslit | Candidate |
| F473I | - | - | Staphylococcus aureus | daptomycin | Reslit | Candidate |
| T492R | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| L14I | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| A243V | - | - | Staphylococcus aureus | cervimycin|vancomycin | Reslit | Candidate |
| R86C | - | - | - | methicillin | Reslit | Candidate |
| R263C | - | single resistance variant, cell wall metabolism sensor histidine kinase WalK | Staphylococcus aureus | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| L10F | - | single resistance variant, cell wall metabolism sensor histidine kinase WalK | Staphylococcus aureus | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| - | - | - | daptomycin | Reslit | Candidate | |
| - | - | - | daptomycin | Reslit | Candidate | |
| - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| walK | Reslit | 4 | vancomycin, daptomycin +1 | Staphylococcus aureus +1 | Japan | 2011, 2015, 2019, 2023 | AP019542|AP019543|AP019545 | - |
| walk/R | Reslit | 1 | vancomycin | Staphylococcus aureus +1 | - | 2021 | - | - |
walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.
The study identifies walK and clpP mutations as contributing to reduced vancomycin susceptibility in Staphylococcus aureus, demonstrating that these mutations lead to increased vancomycin MIC when introduced into a susceptible strain.
Impact of daptomycin resistance on Staphylococcus aureus virulence.
IS256-Mediated Overexpression of the WalKR Two-Component System Regulon Contributes to Reduced Vancomycin Susceptibility in a Staphylococcus aureus Clinical Isolate.
The study identifies mprF and dltABCD as key contributors to DAP resistance in S. aureus isolates, with a non-synonymous mutation in mprF (Trp 424 Cys) playing a significant role in increased DAP resistance.
Antibiotic resistance alters through iron-regulating Sigma factors during the interaction of Staphylococcus aureus and Pseudomonas aeruginosa.
The study shows that the interaction between S. aureus and P. aeruginosa influences antibiotic resistance through changes in the expression of genes such as kpc, mexA-mexB-oprM, oprD, norA, and walk/R, which are involved in carbapenem, ciprofloxacin, and vancomycin resistance.
Emerging resistance in Staphylococcus epidermidis during dalbavancin exposure: a case report and in vitro analysis of isolates from prosthetic joint infections.
No comments yet. Be the first to comment!