Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Transcriptional regulatory protein WalR
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T101S | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T101R | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| V113A | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| P216T | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| P216S | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| A111T | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| F438S | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| S216G | - | - | Listeria monocytogenes | penicillin | Reslit | Candidate |
| C67S | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| A81V | - | - | - | daptomycin | Reslit | Candidate |
| T101M | - | confers resistance to cell wall-targeting antibiotics and sensitivity to tunicamycin | Staphylococcus aureus | vancomycin|ramoplanin|daptomycin | Reslit | Candidate |
| - | - | - | vancomycin | Reslit | Candidate | |
| - | - | - | vancomycin | Reslit | Candidate | |
| - | - | - | daptomycin | Reslit | Candidate | |
| - | - | - | vancomycin | Reslit | Candidate |
IS256-Mediated Overexpression of the WalKR Two-Component System Regulon Contributes to Reduced Vancomycin Susceptibility in a Staphylococcus aureus Clinical Isolate.
The study identifies mprF and dltABCD as key contributors to DAP resistance in S. aureus isolates, with a non-synonymous mutation in mprF (Trp 424 Cys) playing a significant role in increased DAP resistance.
Transcription tuned by S-nitrosylation underlies a mechanism for Staphylococcus aureus to circumvent vancomycin killing.
The study identifies MgrA and WalR as transcriptional regulators that undergo S-nitrosylation, which is crucial for vancomycin resistance in Staphylococcus aureus. Disruption of S-nitrosylation at specific cysteine residues reduces resistance.
No comments yet. Be the first to comment!