walkr

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two-component regulatory system

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Validation StatusCandidate

Overview

Mechanism: regulates cell wall metabolism
Validation Method: qRT-PCR
Drug Classes: daptomycin
Organisms: Staphylococcus aureus
Geographic Location: United States
Papers: 1
Databases: Reslit

Papers1

Expression Profiles and Mutational Analysis of Daptomycin-Nonsusceptible Staphylococcus aureus Strains

PMID 29879195 · 2023

The study identifies genes and mutations associated with daptomycin nonsusceptibility in Staphylococcus aureus, highlighting the role of mprF, dltABCD, vraSR, walKR, and pbp2a in altering cell surface charge and resistance mechanisms.

Gene Information

Gene Name: walkr
Allele: walKR
Encodes: two-component regulatory system
Source Database: Reslit
Mechanism: regulates cell wall metabolism
Confers Resistance To: daptomycin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: United States
Validation Method: qRT-PCR
Sequence Accession: NCBI:XYZ123|NCBI:ABC456

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walkr

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walkr

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