wcaJ

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capsule biosynthesis protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to wcaJ

AMR Rules

Browse AMR rules for wcaJ

Validation StatusCandidate

Overview

Mechanism: mutation leading to resistance
Validation Method: whole genome sequencing and MIC testing
Drug Classes: cephalothin, cefoxitin, ceftazidime
Organisms: Klebsiella pneumoniae 43816, Klebsiella pneumoniae
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G317D	-	-	Klebsiella pneumoniae	ceftazidime	Reslit	Candidate
G317R	-	-	Klebsiella pneumoniae	ceftazidime	Reslit	Candidate

Papers2

Progressive Sub-MIC Exposure of Klebsiella pneumoniae 43816 to Cephalothin Induces the Evolution of Beta-Lactam Resistance without Acquisition of Beta-Lactamase Genes.

PMID 37237790 · 2023

The study shows that progressive sub-MIC exposure of Klebsiella pneumoniae 43816 to cephalothin leads to the evolution of beta-lactam resistance through mutations in rpoB, tetR/acrR, and wcaJ, without acquiring beta-lactamase genes.

Gene Information

Gene Name: wcaJ
Allele: wcaJ
Encodes: capsule biosynthesis protein
Source Database: Reslit
Mechanism: mutation leading to resistance
Confers Resistance To: cephalothincefoxitin
Organisms Tested In: • Klebsiella pneumoniae 43816
Validation Method: whole genome sequencing and MIC testing
Sequence Accession: PMC10215138|PRJNA854906

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

G317D

Klebsiella pneumoniae

ceftazidime

Reslit

Candidate

G317R

Klebsiella pneumoniae

ceftazidime

Reslit

Candidate

wcaJ

Mutations

Gene Information

Browse AMR Genes

wcaJ

Mutations

Gene Information