whiB6

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transcriptional regulator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to whiB6

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: genome-wide association study
Drug Classes: capreomycin, kanamycin
Organisms: Mycobacterium tuberculosis
Geographic Location: Peru
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T2A	-	-	Mycobacterium tuberculosis	kanamycin	Reslit	Candidate

Papers2

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions.

PMID 31086182 · 2019

The study identifies 12 genetic regions and one single nucleotide substitution associated with resistance in Mycobacterium tuberculosis, highlighting the role of non-canonical loci and promoter regions in antibiotic resistance.

Gene Information

Gene Name: whiB6
Allele: whiB6
Encodes: transcriptional regulator
Source Database: Reslit
Confers Resistance To: capreomycinkanamycin
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Peru
Validation Method: genome-wide association study

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whiB6

Mutations

Gene Information

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whiB6

Mutations

Gene Information