xseA

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large subunit of exonuclease VII

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to xseA

AMR Rules

Browse AMR rules for xseA

Validation StatusSupported

Overview

Mechanism: DNA repair
Validation Method: genetic complementation and phenotypic profiling
Drug Classes: quinolones, fluoroquinolones, tosufloxacin
Organisms: Escherichia coli, Salmonella enterica serovar Typhi
Papers: 3
Databases: Reslit

Papers3

The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity.

PMID 29133912 · 2017

The study identifies xseA and mlaFEDCB as critical genes in the MarA regulon that contribute to quinolone and tetracycline resistance, respectively, through mechanisms involving DNA repair and outer membrane integrity.

Gene Information

Gene Name: xseA
Allele: xseA
Encodes: large subunit of exonuclease VII
Source Database: Reslit
Confers Resistance To: quinolones
Organisms Tested In: • Escherichia coli
Validation Method: genetic complementation and phenotypic profiling

A whole-genome screen identifies Salmonella enterica serovar Typhi genes involved in fluoroquinolone susceptibility.

PMID 32514543 · 2020

The study identified several genes involved in fluoroquinolone susceptibility in Salmonella enterica serovar Typhi, including efflux pumps (acrA, acrB, tolC), regulatory genes (marA, phoP), and DNA repair genes (uvrD, xseA).

Gene Information

Gene Name: xseA
Allele: xseA
Encodes: exodeoxyribonuclease large subunit
Source Database: Reslit
Mechanism: DNA repair
Confers Resistance To: fluoroquinolones
Organisms Tested In: • Salmonella enterica serovar Typhi
Validation Method: transposon insertion mutagenesis and MIC determination

Identification of Novel Genes Involved in Escherichia coli Persistence to Tosufloxacin.

PMID 33117736 · 2020

The study identifies 18 genes involved in E. coli persistence to tosufloxacin, including surA and lpcA, which show significant defects in persistence. These genes are periplasmic proteins and enzymes, and their mutants exhibit increased susceptibility to tosufloxacin and other stresses.