yTOP2

type II topoisomerase

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A484V	G1451T	-	Saccharomyces cerevisiae	ciprofloxacin	Reslit	Candidate
G832S	G2495A	-	Saccharomyces cerevisiae	ciprofloxacin	Reslit	Candidate

Papers1

A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents.

Protein Change: A484V, G832S
Nucleotide Change: G2495A
Organisms: Saccharomyces cerevisiae
Confers Resistance To: ciprofloxacin
Validation Method: site-directed mutagenesis and drug sensitivity testing; phenotypic testing
Source Database: Reslit