yhaK

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pirin-like protein

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UniProt

Protein entries specific to yhaK

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Validation StatusCandidate

Overview

Mechanism: regulatory role in adaptive efflux-mediated antibiotic resistance
Validation Method: mutant analysis, complementation, efflux assays, RNA sequencing
Drug Classes: fluoroquinolones, tetracycline
Organisms: Acinetobacter baumannii
Papers: 1
Databases: Reslit

Papers1

Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance.

PMID 37508269 · 2023

The study identified the YhaK pirin-like protein (A1S_3277) as a critical factor in serum-induced adaptive efflux-mediated resistance (AEMR) in Acinetobacter baumannii, contributing to resistance against minocycline and levofloxacin.

Gene Information

Gene Name: yhaK
Allele: yhaK
Encodes: pirin-like protein
Source Database: Reslit
Mechanism: regulatory role in adaptive efflux-mediated antibiotic resistance
Confers Resistance To: fluoroquinolonestetracycline
Organisms Tested In: • Acinetobacter baumannii
Validation Method: mutant analysis, complementation, efflux assays, RNA sequencing
Sequence Accession: COG1741

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yhaK

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yhaK

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