yqhA

View on PubMed

Predicted integral membrane protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to yqhA

AMR Rules

Browse AMR rules for yqhA

Validation StatusCandidate

Overview

Mechanism: Mutation in yqhA (D157Y) may contribute to ciprofloxacin resistance, possibly through altered membrane permeability or stress response
Validation Method: Ultra-deep genome sequencing of evolving populations
Drug Classes: ciprofloxacin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Pathogen-encoded Rum DNA polymerase drives rapid bacterial drug resistance.

PMID 39413207 · 2024

The study shows that the R391-encoded Rum DNA polymerase significantly accelerates the development of ciprofloxacin (CIP) resistance in E. coli under various stress conditions. A single amino acid substitution in RecA, M197D, effectively eliminates the Rum pol-induced CIP resistance.

Gene Information

Gene Name: yqhA
Allele: yqhA
Encodes: Predicted integral membrane protein
Source Database: Reslit
Mechanism: Mutation in yqhA (D157Y) may contribute to ciprofloxacin resistance, possibly through altered membrane permeability or stress response
Confers Resistance To: ciprofloxacin
Organisms Tested In: • Escherichia coli
Validation Method: Ultra-deep genome sequencing of evolving populations

Comments (0)

No comments yet. Be the first to comment!

yqhA

Gene Information

Browse AMR Genes

yqhA

Gene Information