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zapA

ZapA cell division protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to zapA

Browse AMR rules for zapA

Overview

Mechanism: frameshift in zapA
Drug Classes: cefixime
Organisms: Neisseria gonorrhoeae
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
299ins	-	frameshift in zapA	Neisseria gonorrhoeae	cefixime	Reslit	Candidate

Papers1

1

In vitro selection of Neisseria gonorrhoeae unveils novel mutations associated with extended-spectrum cephalosporin resistance.

PMID 35967879 · 2022

Frameshift mutation in zapA was associated with increased cefixime MIC.

Mutation Information

Protein Change: 299ins
Organisms: Neisseria gonorrhoeae
Confers Resistance To: cefixime
Effect on Function: frameshift in zapA
Validation Method: whole-genome sequencing and MIC testing
Source Database: Reslit