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argD

arginine biosynthesis pathway component

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to argD

Browse AMR rules for argD

Overview

Mechanism: loss-of-function
Drug Classes: kanamycin|amikacin|streptomycin|rifampicin|clarithromycin|azithromycin|erythromycin
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
44-51del	-	loss-of-function	Mycobacterium smegmatis, Mycobacterium tuberculosis	kanamycin\|amikacin\|streptomycin\|rifampicin\|clarithromycin\|azithromycin\|erythromycin	Reslit	Candidate
E105X	G314A	loss-of-function	Mycobacterium smegmatis, Mycobacterium tuberculosis	kanamycin\|amikacin\|streptomycin\|rifampicin\|clarithromycin\|azithromycin\|erythromycin	Reslit	Candidate

Papers1

1

Multiform antimicrobial resistance from a metabolic mutation.

PMID 34452915 · 2021

loss-of-function mutation

Mutation Information

argD: p.44-51del argD: p.E105X / c.G314A

Protein Change: 44-51del, E105X
Nucleotide Change: G314A
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Confers Resistance To: kanamycin|amikacin|streptomycin|rifampicin|clarithromycin|azithromycin|erythromycin
Effect on Function: loss-of-function
Validation Method: genetic knockout and complementation
Source Database: Reslit