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Browse Mutations argDE105X

GeneargD

Protein ChangeE105X

Nucleotide ChangeG314A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: loss-of-function
Resistance To: kanamycin|amikacin|streptomycin|rifampicin|clarithromycin|azithromycin|erythromycin
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Multiform antimicrobial resistance from a metabolic mutation.

PMID 34452915 · 2021

loss-of-function mutation

Mutation Information

argD: p.E105X / c.G314A

Protein Change: E105X
Nucleotide Change: G314A
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Confers Resistance To: kanamycin|amikacin|streptomycin|rifampicin|clarithromycin|azithromycin|erythromycin
Effect on Function: loss-of-function
Validation Method: genetic knockout and complementation
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research