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atpC

ε subunit of F-ATP synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to atpC

Browse AMR rules for atpC

Overview

Drug Classes: bedaquiline
Organisms: Mycobacterium smegmatis
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
W16A	TGG->GCG	-	Mycobacterium smegmatis	bedaquiline	Reslit	Candidate

Papers1

1

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase.

PMID 27620476 · 2016

Replacement of tryptophan with alanine led to bedaquiline hypersusceptibility.

Mutation Information

atpC: p.W16A / c.TGG->GCG

Protein Change: W16A
Nucleotide Change: TGG->GCG
Organisms: Mycobacterium smegmatis
Confers Resistance To: bedaquiline
Validation Method: genetic studies and MIC determination
Source Database: Reslit