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Browse Mutations atpCW16A

GeneatpC

Protein ChangeW16A

Nucleotide ChangeTGG->GCG

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: bedaquiline
Organisms: Mycobacterium smegmatis
Papers: 1

Paper Information1

1

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase.

PMID 27620476 · 2016

Replacement of tryptophan with alanine led to bedaquiline hypersusceptibility.

Mutation Information

atpC: p.W16A / c.TGG->GCG

Protein Change: W16A
Nucleotide Change: TGG->GCG
Organisms: Mycobacterium smegmatis
Confers Resistance To: bedaquiline
Validation Method: genetic studies and MIC determination
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research