Browse AMR Genes

Explore antimicrobial resistance genes from the literature

bla CMY-16

beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to bla CMY-16

Browse AMR rules for bla CMY-16

Overview

Mechanism: reduced inhibition efficacy of avibactam
Drug Classes: aztreonam|avibactam
Organisms: Klebsiella pneumoniae
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y150S	-	reduced inhibition efficacy of avibactam	Klebsiella pneumoniae	aztreonam\|avibactam	Reslit	Candidate
N346H	-	reduced inhibition efficacy of avibactam	Klebsiella pneumoniae	aztreonam\|avibactam	Reslit	Candidate

Papers1

1

In vitro selection of aztreonam/avibactam resistance in dual-carbapenemase-producing Klebsiella pneumoniae.

PMID 31722380 · 2020

Mutation Information

bla CMY-16: p.Y150S bla CMY-16: p.N346H

Protein Change: Y150S, N346H
Organisms: Klebsiella pneumoniae
Confers Resistance To: aztreonam|avibactam
Effect on Function: reduced inhibition efficacy of avibactam
Validation Method: cloning in E. coli + MIC testing
Source Database: Reslit