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Browse Mutations bla CMY-16N346H

Protein ChangeN346H

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced inhibition efficacy of avibactam
Resistance To: aztreonam|avibactam
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

In vitro selection of aztreonam/avibactam resistance in dual-carbapenemase-producing Klebsiella pneumoniae.

PMID 31722380 · 2020

Mutation Information

bla CMY-16: p.N346H

Protein Change: N346H
Organisms: Klebsiella pneumoniae
Confers Resistance To: aztreonam|avibactam
Effect on Function: reduced inhibition efficacy of avibactam
Validation Method: cloning in E. coli + MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research