bla(VIM-20)

metallo-beta-lactamase

Overview

Mechanism: increased protein stability and resistance under low-zinc conditions
Drug Classes: carbapenems
Organisms: Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
H229R	-	increased protein stability and resistance under low-zinc conditions	Escherichia coli	carbapenems	Reslit	Candidate

Papers1

A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions.

The H229R mutation enhances protein stability and resistance under low-zinc conditions.

Protein Change: H229R
Organisms: Escherichia coli
Confers Resistance To: carbapenems
Effect on Function: increased protein stability and resistance under low-zinc conditions
Validation Method: structural analysis and MIC testing
Source Database: Reslit