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Browse Mutations bla(VIM-20)H229R

Genebla(VIM-20)

Protein ChangeH229R

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased protein stability and resistance under low-zinc conditions
Resistance To: carbapenems
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions.

PMID 31744917 · 2019

The H229R mutation enhances protein stability and resistance under low-zinc conditions.

Mutation Information

bla(VIM-20): p.H229R

Protein Change: H229R
Organisms: Escherichia coli
Confers Resistance To: carbapenems
Effect on Function: increased protein stability and resistance under low-zinc conditions
Validation Method: structural analysis and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research