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blaCTX-M-4

class A beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaCTX-M-4

Browse AMR rules for blaCTX-M-4

Overview

Mechanism: reduced slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate
Drug Classes: cefotaxime|cefoxitin
Organisms: Escherichia coli, Salmonella typhimurium
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S237A	-	reduced slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate	Escherichia coli, Salmonella typhimurium	cefotaxime\|cefoxitin	Reslit	Candidate

Papers1

1

Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase (CTX-M-4): involvement of serine 237 in cephalosporin hydrolysis.

PMID 9593162 · 1998

Mutation Information

blaCTX-M-4: p.S237A

Protein Change: S237A
Organisms: Escherichia coli, Salmonella typhimurium
Confers Resistance To: cefotaxime|cefoxitin
Effect on Function: reduced slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate
Validation Method: site-directed mutagenesis and enzymatic activity assays
Source Database: Reslit