ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeS237A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate
Resistance To: cefotaxime|cefoxitin
Organisms: Escherichia coli, Salmonella typhimurium
Papers: 1

Paper Information1

Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase (CTX-M-4): involvement of serine 237 in cephalosporin hydrolysis.

PMID 9593162 · 1998

Mutation Information

blaCTX-M-4: p.S237A

Protein Change: S237A
Organisms: Escherichia coli, Salmonella typhimurium
Confers Resistance To: cefotaxime|cefoxitin
Effect on Function: reduced slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate
Validation Method: site-directed mutagenesis and enzymatic activity assays
Source Database: Reslit

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