blaGES-1

β-lactamase

Overview

Mechanism: impaired catalytic activity
Drug Classes: carbapenems
Organisms: Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii, Mycobacterium tuberculosis
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G170S	-	-	Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii	carbapenems	Reslit	Candidate
A237T	-	impaired catalytic activity	Mycobacterium tuberculosis	carbapenems	Reslit	Candidate

Papers2

Class A Carbapenemases: Mechanisms of Action and Resistance

PMID 26960341

Mutation Information

blaGES-1: p.G170S

Protein Change: G170S
Organisms: Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii
Confers Resistance To: carbapenems
Validation Method: mutagenesis_and_kinetic_studies
Source Database: Reslit

Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of β-lactam–β-lactamase inhibitor combinations.

PMID 24060876 · 2013

Mutation Information

blaGES-1: p.A237T

Protein Change: A237T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: carbapenems
Effect on Function: impaired catalytic activity
Validation Method: site-directed mutagenesis
Source Database: Reslit

Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

G170S

Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter baumannii

carbapenems

Reslit

Candidate

A237T

impaired catalytic activity

Mycobacterium tuberculosis

carbapenems

Reslit

Candidate

blaGES-1

Mutations

Mutation Information

Mutation Information

Browse AMR Genes

blaGES-1

Mutations

Mutation Information

Mutation Information