Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
metallo-beta-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| H151V | - | - | Escherichia coli | ceftazidime|cefepime|imipenem|meropenem|tebipenem | Reslit | Candidate |
| P225A | - | - | Escherichia coli | ceftazidime|cefepime|imipenem|meropenem|tebipenem | Reslit | Candidate |
| R236A | - | - | Escherichia coli | ceftazidime|cefepime|imipenem|meropenem|tebipenem | Reslit | Candidate |
| Y227A | - | - | Escherichia coli | ceftazidime|cefepime|imipenem|meropenem|tebipenem | Reslit | Candidate |
Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase.
Mutants showed altered susceptibility to beta-lactam antibiotics.