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Browse Mutations blaL1aY227A

Protein ChangeY227A

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: ceftazidime|cefepime|imipenem|meropenem|tebipenem
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase.

PMID 36826989 · 2023

Mutants showed altered susceptibility to beta-lactam antibiotics.

Mutation Information

blaL1a: p.Y227A

Protein Change: Y227A
Organisms: Escherichia coli
Confers Resistance To: ceftazidime|cefepime|imipenem|meropenem|tebipenem
Validation Method: susceptibility testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research