blaLRA-5

β-lactamase

Overview

Drug Classes: cephalosporins|penicillin, ampicillin|cephalothin|ceftazidime|cefepime|aztreonam
Organisms: E. coli
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y69Q	-	-	E. coli	cephalosporins\|penicillinampicillin\|cephalothin\|ceftazidime\|cefepime\|aztreonam	Reslit	Candidate
V166E	-	-	E. coli	cephalosporins\|penicillinampicillin\|cephalothin\|ceftazidime\|cefepime\|aztreonam	Reslit	Candidate

Papers1

Proposal of metagenomic-origin LRA-5 as a precursor of active β-lactamases through Tyr69Gln and Val166Glu amino acid substitutions: a functional and structural analysis.

PMID 41312992 · 2026

The wild-type LRA-5 does not confer resistance, but the double substitution Tyr69Gln/Val166Glu enables hydrolytic activity against some β-lactam substrates.

Mutation Information

blaLRA-5: p.Y69Q blaLRA-5: p.V166E

Protein Change: Y69Q, V166E
Organisms: E. coli
Confers Resistance To: cephalosporins|penicillinampicillin|cephalothin|ceftazidime|cefepime|aztreonam
Validation Method: expression in E. coli and MIC testing; kinetic assays and structural analysis
Source Database: Reslit

blaLRA-5

Mutations

Mutation Information

Browse AMR Genes

blaLRA-5

Mutations

Mutation Information