ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeV166E

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: cephalosporins|penicillin, ampicillin|cephalothin|ceftazidime|cefepime|aztreonam
Organisms: E. coli
Papers: 1

Paper Information1

Proposal of metagenomic-origin LRA-5 as a precursor of active β-lactamases through Tyr69Gln and Val166Glu amino acid substitutions: a functional and structural analysis.

PMID 41312992 · 2026

The wild-type LRA-5 does not confer resistance, but the double substitution Tyr69Gln/Val166Glu enables hydrolytic activity against some β-lactam substrates.

Mutation Information

blaLRA-5: p.V166E

Protein Change: V166E
Organisms: E. coli
Confers Resistance To: cephalosporins|penicillinampicillin|cephalothin|ceftazidime|cefepime|aztreonam
Validation Method: expression in E. coli and MIC testing; kinetic assays and structural analysis
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

Mutation Information

Browse AMR Mutations

Mutation Information