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blaOXA-10

class D beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaOXA-10

Browse AMR rules for blaOXA-10

Overview

Mechanism: enhances carbapenemase activity
Drug Classes: meropenem|ertapenem|doripenem|temocillin
Organisms: Escherichia coli, Enterobacter cloacae
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V117L	-	enhances carbapenemase activity	Escherichia coli, Enterobacter cloacae	meropenem\|ertapenem\|doripenem\|temocillin	Reslit	Candidate

Papers1

1

Characterization of the First OXA-10 Natural Variant with Increased Carbapenemase Activity.

PMID 30397053 · 2019

The Val117Leu substitution enhances carbapenemase activity

Mutation Information

blaOXA-10: p.V117L

Protein Change: V117L
Organisms: Escherichia coli, Enterobacter cloacae
Confers Resistance To: meropenem|ertapenem|doripenem|temocillin
Effect on Function: enhances carbapenemase activity
Validation Method: steady-state kinetic experiments
Source Database: Reslit