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Browse Mutations blaOXA-10V117L

Protein ChangeV117L

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: enhances carbapenemase activity
Resistance To: meropenem|ertapenem|doripenem|temocillin
Organisms: Escherichia coli, Enterobacter cloacae
Papers: 1

Paper Information1

1

Characterization of the First OXA-10 Natural Variant with Increased Carbapenemase Activity.

PMID 30397053 · 2019

The Val117Leu substitution enhances carbapenemase activity

Mutation Information

blaOXA-10: p.V117L

Protein Change: V117L
Organisms: Escherichia coli, Enterobacter cloacae
Confers Resistance To: meropenem|ertapenem|doripenem|temocillin
Effect on Function: enhances carbapenemase activity
Validation Method: steady-state kinetic experiments
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research