Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
serine β-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S64G | - | increased thermostability | - | cephalosporins | Reslit | Candidate |
| S64T | - | Enterobacter cloacae | cephalosporins | Reslit | Candidate | |
| - | - | Enterobacter cloacae, Escherichia coli | cefepime|ceftazidime | Reslit | Candidate | |
| Y150F | - | Enterobacter cloacae | cephalosporins | Reslit | Candidate |
Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine β-Lactamases by Relieving Steric Strain.
Identification of residues critical for catalysis in a class C beta-lactamase by combinatorial scanning mutagenesis.
Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime.
The wild-type blaP99 gene confers resistance to a wide range of β-lactams but not to cefepime.