ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeS64G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased thermostability
Resistance To: cephalosporins
Papers: 1

Paper Information1

Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine β-Lactamases by Relieving Steric Strain.

PMID 27073009 · 2016

Mutation Information

blaP99: p.S64G

Protein Change: S64G
Confers Resistance To: cephalosporins
Effect on Function: increased thermostability
Validation Method: thermal denaturation experiments and X-ray crystallography
Source Database: Reslit

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