blaPER-4

beta-lactamase

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	G360C	reduced avibactam affinity and high-level CZA resistance	Pseudomonas aeruginosa	ceftazidime\|ceftazidime avibactam	Reslit	Candidate

Papers1

Genomic epidemiology and ceftazidime-avibactam high-level resistance mechanisms of Pseudomonas aeruginosa in China from 2010 to 2022.

The S130T mutation in blaPER-4 leads to reduced avibactam affinity and high-level CZA resistance.

Nucleotide Change: G360C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftazidime|ceftazidime avibactam
Effect on Function: reduced avibactam affinity and high-level CZA resistance
Validation Method: kinetic analysis and structural modeling
Source Database: Reslit