Home Browse Genes Browse Mutations Download Collaborators About

Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research

Home Browse Genes Browse Mutations Download Collaborators About

Browse Mutations blaPER-4G360C

Nucleotide ChangeG360C

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced avibactam affinity and high-level CZA resistance
Resistance To: ceftazidime|ceftazidime avibactam
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

1

Genomic epidemiology and ceftazidime-avibactam high-level resistance mechanisms of Pseudomonas aeruginosa in China from 2010 to 2022.

PMID 38406830 · 2024

The S130T mutation in blaPER-4 leads to reduced avibactam affinity and high-level CZA resistance.

Mutation Information

blaPER-4: c.G360C

Nucleotide Change: G360C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: ceftazidime|ceftazidime avibactam
Effect on Function: reduced avibactam affinity and high-level CZA resistance
Validation Method: kinetic analysis and structural modeling
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research