Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
beta-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S130G | - | prevents irreversible cross-linking of the inhibitor to Ser130, confers resistance to β-lactam-clavulanate combinations | Escherichia coli, E. coli | penicillinampicillin|clavulanic acid|sulbactam|tazobactam | Reslit | Candidate |
| R164S | - | - | E. coli | ceftazidime|cefotaxime | Reslit | Candidate |
| E104K | - | - | E. coli | ceftazidime|cefotaximeceftazidime|ampicillin | Reslit | Candidate |
| G238S | - | - | E. coli | ceftazidime|cefotaxime | Reslit | Candidate |
| S268G | - | - | E. coli | ceftazidime | Reslit | Candidate |
| S164F | - | - | - | ampicillin|penicillin | Reslit | Candidate |
| R244C | - | confers resistance to β-lactam-clavulanate combinations | E. coli | ampicillin|clavulanic acid|sulbactam|tazobactam | Reslit | Candidate |
| R244S | - | confers resistance to β-lactam-clavulanate combinations | E. coli | ampicillin|clavulanic acid|sulbactam|tazobactam | Reslit | Candidate |
| N276D | - | confers resistance to β-lactam-clavulanate combinations | E. coli | ampicillin|clavulanic acid|sulbactam|tazobactam | Reslit | Candidate |
| M69L | - | confers resistance to β-lactam-clavulanate combinations | E. coli | ampicillin|clavulanic acid|sulbactam|tazobactam | Reslit | Candidate |
| A237R | - | - | E. coli | cefixime | Reslit | Candidate |
| A237K | - | - | E. coli | cefixime | Reslit | Candidate |
| - | - | Escherichia coli, Klebsiella pneumoniae | amoxicillin|amoxicillin clavulanic acid | Reslit | Candidate |
Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.
The Ser130Gly substitution prevents irreversible cross-linking of the inhibitor to Ser130, leading to resistance.
Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.
These mutations were introduced into the TEM-1 beta-lactamase to study their effects on resistance to beta-lactam antibiotics and beta-lactamase inhibitors.
Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors.
The mutations were identified through DNA shuffling and mutagenesis experiments.
Antibiotic resistance in Pakistan: a systematic review of past decade.
Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
Mutant enzymes with replacements of Met69, Arg244, and Asn276 had been reported to confer resistance to beta-lactam-clavulanate combinations.
Covalent docking and molecular dynamics simulations reveal the specificity-shifting mutations Ala237Arg and Ala237Lys in TEM beta-lactamase.
Both mutations enhance resistance to cefixime by forming salt bridges with the drug's negatively-charged R-group.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
associated with increased beta-lactamase production