ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeN276D

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: confers resistance to β-lactam-clavulanate combinations
Resistance To: ampicillin|clavulanic acid|sulbactam|tazobactam
Organisms: E. coli
Papers: 1

Paper Information1

Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.

PMID 9660980 · 1998

Mutant enzymes with replacements of Met69, Arg244, and Asn276 had been reported to confer resistance to beta-lactam-clavulanate combinations.

Mutation Information

blaTEM-1: p.N276D

Protein Change: N276D
Organisms: E. coli
Confers Resistance To: ampicillin|clavulanic acid|sulbactam|tazobactam
Effect on Function: confers resistance to β-lactam-clavulanate combinations
Validation Method: MIC testing
Source Database: Reslit

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