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Explore antimicrobial resistance genes from the literature

dat

d-amino acid aminotransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to dat

Browse AMR rules for dat

Overview

Drug Classes: beta lactams
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S180F	-	-	-	beta lactams	Reslit	Candidate

Papers1

1

A S(180)F substitution in D-alanine aminotransferase confers resistance to β-chloro-D-alanine in Staphylococcus aureus.

PMID 41232672 · 2025

The S180F mutation in Dat reduces enzyme activity and confers resistance to BCDA.

Mutation Information

Protein Change: S180F
Confers Resistance To: beta lactams
Validation Method: mutant analysis and enzyme kinetics
Source Database: Reslit