Browse AMR Genes

Explore antimicrobial resistance genes from the literature

dltX

membrane-associated small protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to dltX

Browse AMR rules for dltX

Overview

Mechanism: increased susceptibility to polymyxin B
Drug Classes: polymyxin b
Organisms: Streptococcus pyogenes
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
1del	-	increased susceptibility to polymyxin B	Streptococcus pyogenes	polymyxin b	Reslit	Candidate

Papers1

1

The Dlt and LiaFSR systems derepress SpeB production independently in the Δpde2 mutant of Streptococcus pyogenes.

PMID 38029265 · 2023

Deletion of dltX increases susceptibility to polymyxin B.

Mutation Information

Protein Change: 1del
Organisms: Streptococcus pyogenes
Confers Resistance To: polymyxin b
Effect on Function: increased susceptibility to polymyxin B
Validation Method: MIC measurement
Source Database: Reslit