Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
sensor kinase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G226D | - | reduced expression of the outer membrane porins OmpC and OmpF | Salmonella typhimurium | cephalothin|cefaclor | Reslit | Candidate |
| L88F | - | - | Klebsiella pneumoniae | carbapenems | Reslit | Candidate |
| V145G | - | - | Klebsiella pneumoniae | cefiderocol | Reslit | Candidate |
| E212V | - | - | Escherichia coli | ceftriaxone | Reslit | Candidate |
| S242G | - | - | Escherichia coli | ceftriaxone | Reslit | Candidate |
| R397H | - | - | Salmonella enterica | cefotaxime | Reslit | Candidate |
| P148S | - | - | Klebsiella pneumoniae | cefiderocol | Reslit | Candidate |
| F123L | - | - | Escherichia coli | tetracycline | Reslit | Candidate |
| T402M | - | - | Escherichia coli | ampicillin | Reslit | Candidate |
| T247P | - | loss-of-function | Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa | cefiderocol | Reslit | Candidate |
| R397C | - | two-component system sensor histidine kinase EnvZ | Klebsiella pneumoniae | ceftazidime avibactam | Reference Gene Catalog | Candidate |
| I412L | - | two-component system sensor histidine kinase EnvZ | Klebsiella pneumoniae | ceftazidime avibactam | Reference Gene Catalog | Candidate |
Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimurium.
In-Human Multiyear Evolution of Carbapenem-Resistant Klebsiella pneumoniae Causing Chronic Colonization and Intermittent Urinary Tract Infections: A Case Study.
Effects of different carbapenemase and siderophore production on cefiderocol susceptibility in Klebsiella pneumoniae.
Identification of Multiple Low-Level Resistance Determinants and Coselection of Motility Impairment upon Sub-MIC Ceftriaxone Exposure in Escherichia coli.
mutations in envZ contribute to low-level ceftriaxone resistance
Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella.
associated with increased cefotaxime MIC and reduced biofilm formation
In vitro antimicrobial activity and resistance mechanisms of cefiderocol against clinical carbapenem-resistant gram-negative bacteria.
Missense mutation in envZ was detected in K. pneumoniae.
Pervasive Selection for Clinically Relevant Resistance and Media Adaptive Mutations at Very Low Antibiotic Concentrations.
A shared mechanism of multidrug resistance in laboratory-evolved uropathogenic Escherichia coli.
In vitro resistance development gives insights into molecular resistance mechanisms against cefiderocol.
Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC-producing Enterobacteriaceae.
envZ