Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
c-di-AMP phosphodiesterase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| E327* | - | - | Clostridioides difficile | vancomycin | Reslit | Candidate |
| E297K | - | - | - | oxacillin|penicillin|amoxicillin clavulanic acid|ceftaroline | Reslit | Candidate |
| Y475C | - | - | - | oxacillin|penicillin|amoxicillin clavulanic acid|ceftaroline | Reslit | Candidate |
| H621Y | - | - | - | oxacillin|penicillin|amoxicillin clavulanic acid|ceftaroline | Reslit | Candidate |
| I456V | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| D561E | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| E183A | - | - | - | nafcillin|oxacillin | Reslit | Candidate |
| F241R | - | - | - | nafcillin|oxacillin | Reslit | Candidate |
| N182K | - | cyclic-di-AMP phosphodiesterase GdpP | Staphylococcus aureus | nafcillincephalosporins | ReslitReference Gene Catalog | Candidate |
| S222F | - | - | Staphylococcus aureus | nafcillin | Reslit | Candidate |
| I52V | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
Mechanisms and impact of antimicrobial resistance in Clostridioides difficile.
In Vitro Selection of High-Level Beta-Lactam Resistance in Methicillin-Susceptible Staphylococcus aureus.
Detected in SA0707 strain
Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility.
Mutations in GdpP contribute to reduced oxacillin susceptibility.
Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.
loss-of-function mutation
Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant Staphylococcus aureus.
A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.
gdpP
Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit.