hisD

histidinal dehydrogenase

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D41Y	G122T	-	E. coli, Bacillus siamensis	macrolides	Reslit	Candidate

Papers1

Adaptive Laboratory Evolution of Streptomyces sp. A72 for Enhanced Production of Macrolide Lantibiotics

mutation in hisD gene causes a nonsynonymous amino acid change (D41Y)

Protein Change: D41Y
Nucleotide Change: G122T
Organisms: E. coli, Bacillus siamensis
Confers Resistance To: macrolides
Validation Method: overexpression in E. coli and measurement of MLNs production and resistance
Source Database: Reslit