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Browse Mutations hisDD41Y

GenehisD

Protein ChangeD41Y

Nucleotide ChangeG122T

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: macrolides
Organisms: E. coli, Bacillus siamensis
Papers: 1

Paper Information1

1

Adaptive Laboratory Evolution of Streptomyces sp. A72 for Enhanced Production of Macrolide Lantibiotics

PMID 35854349 · 2023

mutation in hisD gene causes a nonsynonymous amino acid change (D41Y)

Mutation Information

hisD: p.D41Y / c.G122T

Protein Change: D41Y
Nucleotide Change: G122T
Organisms: E. coli, Bacillus siamensis
Confers Resistance To: macrolides
Validation Method: overexpression in E. coli and measurement of MLNs production and resistance
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research